World number one Scottie Scheffler returns to defend the Claret Jug.
The American, 30, is in search of his fifth major title and first since being crowned the champion golfer of the year at Royal Portrush 12 months ago.
Scheffler, has not been at his imperious best this year but is still considered the pre-tournament betting favourite.
He is attempting to become the first golfer since Padraig Harrington in 2008 to win back-to-back Opens.
Elsewhere, there are plenty of star names that will fancy their chances at the final men's major of the year.
Masters champion Rory McIlroy will tee off in the afternoon wave in a star-studded group that includes Xander Schauffele and Matthew Fitzpatrick.
The trio are out at 15:15 BST.
Meanwhile, no English golfer has won The Open since Sir Nick Faldo triumphed at Muirfield in 1992.
Aside from the aforementioned Fitzpatrick, Justin Rose, Tyrrell Hatton and recent US PGA Championship winner Aaron Rai will fancy there chaces.
The loudest cheers will likely be reserved for Tommy Fleetwood, though, who grew up just 10 minutes from Royal Birkdale.
For Fleetwood to lift the Claret Jug would be a story for the ages.
Keep up to date with the first round of the 154th Open Championship below.
BST
09:58 Scottie Scheffler, Tyrrell Hatton, Bryson Dechambeau
10:09 Jordan Spieth, Tommy Fleetwood, Jon Rahm
14:53 Shane Lowry, Aaron Rai, Brooks Koepka
15:04 Cameron Young, Wyndham Clark, Ludvig Aberg
15:15 Rory McIlroy, Xander Schauffele, Matt Fitzpatrick
Scotland's number one, Bob MacIntyre, certainly knows his way around a links.
And he's made a fast start this morning, making consecutive birdies right out of the gate.
He sits atop the leaderboard on two-under.
Matthew Baldwin, Thomas Detry and Matthew Southgate are also the right side of par.
England's Matthew Baldwin, a member of Royal Birkdale, had the honour of hitting the opening tee shot at the 154th Open.
Baldwin earned his spot in the 156-man field by advancing through final qualifying last month.
The 40-year-old puffed out his cheeks before sending his tee shot down the right side of the fairway.
He made a steady par and has backed it up with two more pars at the second and third.
