The official PGA Tour communications team confirmed the news on Tuesday that Finau has withdrawn through injury.
He has been replaced in the field by Kevin Chappell in the $8.1m prize purse tournament in Georgia.
Related: Tony Finau, WITB?
The news will come as a blow for Finau considering he won his fifth PGA Tour victory last week when he cruised to victory at the Houston Open at Memorial Park Golf Course.
Finau picked up a cheque for $1,512,000.
That was after he pretended to almost go full Happy Gilmore on the first tee.
The victory was Finau's third win in seven starts, stretching to the back end of last season when he won back-to-back events at the 3M Open and Rocket Mortgage Classic.
It was an emotional victory in Houston for Finau, and he reflected on the win by telling the media:
Field changes at The RSM Classic:— PGA TOUR Communications (@PGATOURComms) November 15, 2022
William McGirt WD; replaced by Sung Kang
Tony Finau WD (injury); replaced by Kevin Chappell
Elsewhere, the defending champion of the RSM Classic - Jason Kokrak - won't be teeing it up this week.
That is because Kokrak has joined the LIV Golf League and is currently suspended by the PGA Tour pending the outcome of legal proceedings.
Kokrak was initially one of 11 players who was named as a plaintiff in the antitrust lawsuit against the PGA Tour in August, but he has since dropped out.